WASHINGTON (AP) -- A specimen of the influenza virus
that killed 21 million people in the 1918 worldwide epidemic has been recovered from the
frozen remains of a flu victim buried in Alaska.
Researchers at the Armed Forces Institute of Pathology announced Thursday that biopsy
specimens from a frozen corpse exhumed from a cemetery in Brevig Mission, Alaska, contain
genetic material from the killer flu.
Experts said that analyzing the 1918 virus genetic pattern will help science learn how
that particular virus was able to kill so many people worldwide and will help researchers
prepare vaccines to protect against the virus if it breaks out again.
Army researchers last year identified the flu virus in preserved lung specimens taken
during autopsies of soldiers killed by the flu in 1918 at military bases in Fort Jackson,
South Carolina, and Camp Upton, New York.
Town lost nearly all of its residents
The new specimen was taken from the lung of one of 72 people buried in a mass grave after
the flu swept through Brevig Mission, then known as Teller Mission, in 1918. The small
town lost 85 percent of its population in a single week.
Dr. Johan Hultin, a retired San Francisco pathologist, exhumed four bodies from the mass
grave and found that one, an obese woman, was well-preserved. Tissue from her lung was
later found to contain genes from the killer flu.
Dr. Jeffery K. Taubenberger of the Armed Forces Institute of Pathology said last year that
the genetic pattern of the 1918 flu virus is unlike any other flu bug, but is closely
related to the so-called "swine flu."
Taubenberger said although the disease that caused the worldwide epidemic was called
"Spanish flu," the virus apparently was a mutation that evolved in American pigs
and was spread around the globe by U.S. troops mobilized for World War I.
Flu virus from swine believed most harmful to people
The finding supports a widespread theory that flu viruses from swine are the most virulent
for humans. Two other flu viruses spread worldwide since 1918 -- the Asian flu in 1957 and
the Hong Kong flu in 1968 -- both mutated in pigs.
Most experts believe that flu viruses reside harmlessly in birds, where they are
genetically stable. Occasionally, a virus from birds will infect pigs. The swine immune
system attacks the virus, forcing it to change genetically to survive. The result is a new
virus.
The 1918 flu genes were first isolated last year from the preserved lung tissue of an Army
private who died at Fort Jackson, South Carolina. Army doctors in 1918 conducted autopsies
on some of the 43,000 servicemen killed by the flu and preserved some specimens in
formaldehyde and wax.
The 1918 flu epidemic caused about 700,000 deaths in the United States, and about a
quarter of the nation's population contracted the illness.
© Copyright 1998 The Associated Press
